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Septins: Regulators of Protein Stability

Olga Vagin1, David O Beenhouwer2

  • 1Department of Physiology, Geffen School of Medicine at UCLALos Angeles, CA, USA; VA Greater Los Angeles Healthcare SystemLos Angeles, CA, USA.

Frontiers in Cell and Developmental Biology
|January 10, 2017
PubMed
Summary

Septins are key GTPases that stabilize proteins by interacting with degradation pathways and cellular components. This review highlights their protective roles for botulinum neurotoxin, EGFR, ErbB2, and HIF-1α.

Keywords:
botulinum toxinshypoxia-inducible factor 1αprotein stabilityreceptor tyrosine kinasesseptins

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