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Bone marrow derived stem cell therapy for type 2 diabetes mellitus.
Tarek Wehbe1, Nassim Abi Chahine2, Salam Sissi3
1Hematology Department, the Lebanese Canadian and Notre Dame University Hospitals, Beirut, Lebanon.
Stem Cell Investigation
|January 10, 2017
Summary
Autologous bone marrow stem cell therapy shows promise for type 2 diabetes. Six patients experienced improved glucose control and reduced medication needs with no adverse effects.
Area of Science:
- Regenerative Medicine
- Endocrinology
- Diabetes Research
Background:
- Type 2 diabetes (T2D) is a chronic metabolic disorder requiring ongoing management.
- Current treatments aim to control blood glucose but often have limitations and side effects.
- Stem cell therapy offers a potential novel approach for T2D treatment.
Observation:
- Six patients with T2D received autologous bone marrow mononuclear stem cells (BM-MNSCs) via arterial infusion.
- No myeloablative or immunosuppressive preconditioning was administered.
- Infusions targeted the celiac and superior mesenteric arteries.
Findings:
- 83% of patients (5/6) achieved normalized fasting glucose and HbA1C levels.
- Average HbA1C reduction was 2.2 points.
- Significant decrease in medication requirements was observed.
- Patients reported improved energy and stamina.
- Diabetic complications showed improvement or stabilization in three patients.
- Responses lasted from 6 months to 2 years.
- No significant adverse events were reported.
Implications:
- Autologous BM-MNSC infusion presents a potentially safe and effective therapeutic strategy for T2D.
- This approach may offer a regenerative solution for diabetes management.
- Further research is warranted to confirm these findings in larger cohorts.
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