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Serum fructosamine in diabetic pregnancy
K J Pasi1, M J Toop, B L Cockrill
1Dept of Clinical Chemistry, Queen Elizabeth Hospital, Birmingham, UK.
Diabete & Metabolisme
|July 1, 1989
Summary
Serum fructosamine, a marker for diabetes control during pregnancy, correlates with birth weight. This finding suggests glucose management throughout pregnancy is crucial for fetal development.
Area of Science:
- Endocrinology
- Clinical Chemistry
Background:
- Glycaemic control during pregnancy is vital for maternal and fetal health.
- Standard markers like HbA1c may not fully capture glucose fluctuations throughout gestation.
Purpose of the Study:
- To evaluate serum fructosamine as a measure of glycaemic control in diabetic pregnancies.
- To assess the correlation between serum fructosamine and birth weight ratio.
Main Methods:
- Serum fructosamine was measured in 41 diabetic patients throughout pregnancy.
- Corrected serum fructosamine was calculated using serum protein concentrations.
- Comparisons were made with clinic blood glucose and HbA1c.
Main Results:
- Corrected serum fructosamine significantly decreased by the end of pregnancy.
- Corrected serum fructosamine showed significant positive correlations with birth weight ratio (r = 0.51-0.67).
- HbA1c did not consistently correlate with birth weight ratio.
Conclusions:
- Corrected serum fructosamine is a valuable indicator of glycaemic control in diabetic pregnancies.
- Glucose control throughout pregnancy, not just the third trimester, influences birth weight.