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The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer

Vladimir Stanislavovich Rogovskii1

  • 1Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Bolshaya Pirogovskaya st. 9a, Moscow, 119435, Russian Federation.

Current Cancer Drug Targets
|January 10, 2017
PubMed
Abstract

Insights

Chronic inflammation drives cancer progression by promoting immune tolerance, allowing tumors to evade immune detection. Understanding these links is crucial for developing new cancer therapies.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Chronic inflammation is a critical factor in cancer development.
  • Immune tolerance in cancer facilitates tumor escape from immune surveillance.
  • The precise mechanisms linking inflammation and immune tolerance in cancer remain incompletely understood.

Purpose of the Study:

  • To elucidate the primary mechanisms connecting inflammation and immune tolerance in the context of cancer.
  • To review current drug targets aimed at modulating inflammation in cancer treatment.

Main Methods:

  • Review and synthesis of existing scientific literature on inflammation and immune tolerance in cancer.
  • Analysis of established and emerging therapeutic strategies targeting inflammatory pathways in oncology.

Main Results:

  • Inflammation plays a key role in mediating tumor-induced immune tolerance.
  • The induction and sustained presence of chronic inflammation represent a common strategy employed by tumors to establish immune tolerance.

Conclusions:

  • Inflammation is a fundamental driver of tumor-induced immune tolerance.
  • Targeting inflammatory pathways offers potential therapeutic avenues for overcoming immune evasion in cancer.
Keywords:
Inflammationcancer immunotherapyimmune toleranceresolutiontumor immunologytumor-induced tolerance

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