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Identical twins with idiopathic external hydrocephalus.
D B Cundall1, J T Lamb, S H Roussounis
1Department of Paediatrics and Child Health, St. James University Hospital, Leeds.
Developmental Medicine and Child Neurology
|October 1, 1989
Summary
Idiopathic external hydrocephalus in identical twins suggests a genetic cause. This condition presented with early motor delays but showed quick recovery.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Idiopathic external hydrocephalus (IEH) is a rare condition characterized by cerebrospinal fluid accumulation outside the brain.
- Understanding the etiology of IEH is crucial for effective management and prognosis.
Observation:
- This report details a case of IEH occurring in monozygotic (identical) twins.
- The twins presented with specific computerised tomographic (CT) findings suggestive of the condition.
Findings:
- The observed CT features in the twins were associated with significant early gross motor delay.
- Remarkably, the affected twins demonstrated rapid improvement in their motor function over time.
Implications:
- The co-occurrence of IEH in identical twins strongly supports a genetic predisposition or basis for this syndrome.
- Further research into the genetic underpinnings of IEH may reveal novel diagnostic and therapeutic targets.