Related Experiment Video For Non-coding RNA
Updated: Mar 9, 2026
Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
H19 non-coding RNA in urine cells detects urothelial carcinoma: a pilot study
Ilan Gielchinsky1, Michal Gilon2, Rasha Abu-Lail2
1a Department of Urology , Hadassah - Hebrew University Medical Centre , Jerusalem , Israel.
Context:
Urothelial carcinoma (UC) is common and highly recurrent. Diagnosis and follow-up involve invasive cystoscopies.
Objective:
To evaluate H19 RNA in urine cells as diagnostic tool for UC.
Materials And Methods:
RT-PCR analysis of urine samples from healthy volunteers and UC patients.
Results:
H19 RNA was unequivocally detected in the urine of 90.5% of patients and 25.9% of controls. H19 copies were three orders of magnitude higher in patients. Receiver operating characteristic analysis showed an area under the curve of 0.933.
Conclusions:
This pilot study shows that urinary cell H19 is a highly sensitive test for UC and pending verification could transform patient management.
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