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CK2-An Emerging Target for Neurological and Psychiatric Disorders

Julia Castello1,2, Andre Ragnauth3,4, Eitan Friedman5,6

  • 1Department of Physiology, Pharmacology and Neuroscience, City University of New York School of Medicine, New York, NY 10031, USA. julia.csaval@gmail.com.

Pharmaceuticals (Basel, Switzerland)
|January 10, 2017
PubMed

Insights

Protein kinase CK2 (CK2) is overexpressed in cancers and crucial for brain function. Inhibiting CK2 shows promise for treating brain tumors and neurological disorders.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Oncology

Background:

  • Protein kinase CK2 (CK2) is increasingly recognized for its overexpression in solid tumors and multiple myelomas.
  • CK2 plays a critical role in cell survival pathways and is upregulated in glioblastoma multiforme.
  • The kinase is highly expressed in the mammalian brain, regulating neuronal and glial homeostasis.

Approach:

  • This review synthesizes recent research on CK2's role in neuronal functions.
  • It examines evidence from preclinical models and knockout mice studies.
  • The focus is on CK2's potential as a therapeutic target.

Key Points:

  • CK2 overexpression is linked to various cancers, including glioblastoma.
  • Pharmacological inhibition of CK2 has demonstrated efficacy in reducing tumor progression.
  • CK2 is vital for brain development, neuronal activity, and behavior.

Conclusions:

  • CK2 is a significant regulator of neuronal functions.
  • Targeting CK2 presents a promising strategy for treating neurological and psychiatric disorders.
Keywords:
CK2CK2 inhibitorsCK2 knockoutCK2 substratesGPCRsneurodegenerationsignalingsynapse

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