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Updated: Mar 9, 2026

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
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PrimPol-Prime Time to Reprime.

Thomas A Guilliam1, Aidan J Doherty2

  • 1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton BN1 9RQ, UK. T.Guilliam@sussex.ac.uk.

Genes
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

Primase-polymerase (PrimPol) is a key enzyme that helps eukaryotic DNA replication forks overcome obstacles. This review details PrimPol

Keywords:
AEPDNA replicationPrimPoldamage tolerancepolymeraseprimaseprimingtranslesion synthesis

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • DNA replication requires overcoming obstacles for timely genome duplication.
  • Eukaryotic replication fork progression is crucial for maintaining genomic stability.

Approach:

  • This review synthesizes current literature on PrimPol's functions.
  • It focuses on PrimPol's role in leading strand repriming.
  • Mechanisms of PrimPol recruitment and regulation are discussed.

Key Points:

  • PrimPol is a versatile enzyme with template-dependent and independent synthesis activities.
  • It belongs to the archaeo-eukaryotic primase (AEP) superfamily.
  • PrimPol plays a vital role in eukaryotic DNA replication fork progression.

Conclusions:

  • PrimPol is an emerging key player in maintaining replication fork integrity.
  • Further research is needed to fully elucidate PrimPol's mechanisms and regulation.
  • Understanding PrimPol's roles can reveal new insights into genome duplication and stability.