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Related Experiment Video

Updated: Mar 9, 2026

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Published on: March 6, 2016

Enriching Nanoparticles via Acoustofluidics.

Zhangming Mao¹, Peng Li², Mengxi Wu^1,3

¹Department of Engineering Science and Mechanics, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

|January 10, 2017

Summary

This study introduces a low-power acoustofluidic chip for concentrating tiny particles. The chip uses acoustic streaming and radiation force to focus nanoparticles for enhanced signal detection in assays.

Keywords:

acoustic streaming acoustic tweezers acoustofluidics nanoparticle enrichment surface acoustic waves

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Last Updated: Mar 9, 2026

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

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Published on: March 6, 2016

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Fabrication of Nanoheight Channels Incorporating Surface Acoustic Wave Actuation via Lithium Niobate for Acoustic Nanofluidics

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Published on: February 5, 2020

Area of Science:

Biotechnology
Nanotechnology
Fluid Dynamics

Background:

Focusing and enriching submicrometer and nanometer scale objects is critical for various scientific and medical applications.
Existing methods for particle manipulation can be complex or energy-intensive.

Purpose of the Study:

To develop a simple, low-power acoustofluidic chip for efficient particle focusing and enrichment.
To demonstrate the chip's capability in concentrating nanoparticles for enhanced signal detection.

Main Methods:

Utilizing low-power acoustic waves to generate single vortex acoustic streaming within a glass capillary.
Employing acoustic radiation force alongside acoustic streaming for particle manipulation.
Conducting numerical simulations to understand vortex formation and experimental verification with various nanoparticles.

Main Results:

Successfully generated single vortex acoustic streaming using only 5V power.
Demonstrated the enrichment of submicrometer and nanometer-sized particles (80-500 nm) including silica and polystyrene.
Applied the chip to an immunoassay, concentrating nanoparticles to amplify biomarker detection signals.

Conclusions:

The developed acoustofluidic chip offers a simple, functional, and power-efficient solution for particle manipulation.
The technology shows significant promise for point-of-care applications requiring sensitive detection and sample enrichment.