Related Experiment Video
Updated: Mar 9, 2026

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs
Published on: May 5, 2023
Extracellular matrix proteins as temporary coating for thin-film neural implants
Frederik Ceyssens1, Marjolijn Deprez, Neill Turner
1Department of ESAT-MICAS, KULeuven, Leuven, Belgium.
Objective:
This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (µECOG) implants.
Approach:
Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group.
Main Results:
After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas.
Significance:
The study shows that ECM sheets are a suitable temporary coating for thin µECOG neural implants.
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