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Updated: Mar 9, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Revision Knee Arthroplasty in Patients with Inherited Bleeding Disorders: A Single-Center Experience
Andrzej Kotela1,2, Magdalena Wilk-Frańczuk3, Piotr Żbikowski2
1Department of Orthopaedics and Traumatology of the Musculoskeletal System, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
Insights
Revision total knee arthroplasty (TKA) in patients with inherited bleeding disorders (IBDs) yields better outcomes for aseptic loosening than infection. Infection cases required multiple interventions and had complications, unlike aseptic loosening cases.
Area of Science:
- Orthopedic Surgery
- Hematology
- Arthroplasty
Background:
- Patients with inherited bleeding disorders (IBDs) experience poorer outcomes and higher complication rates after total knee arthroplasty (TKA).
- Revision TKA is a growing concern for IBD patients due to increased risks.
- This study evaluates revision TKA outcomes specifically in patients with IBD.
Observation:
- A retrospective cohort study assessed hemophilia patients undergoing revision TKA from 2010 to 2015.
- Clinical status, pain, satisfaction, radiological findings, complications, and reinterventions were analyzed.
- Patients were evaluated using the Knee Society Score and Numeric Rating Scale.
Findings:
- Revision TKA for aseptic loosening resulted in very good outcomes, with all patients requiring only single-stage procedures.
- Revision TKA for infection led to inferior results, necessitating multiple interventions and resulting in complications.
- Complications were exclusively observed in patients with infected implants.
Implications:
- Failure mode significantly impacts revision TKA outcomes in IBD patients, with infection being a major concern.
- Further high-quality research is essential due to the unique challenges and limited data in this patient population.
- Understanding these differences can guide surgical strategies and improve patient management for revision TKA in IBD.
Abstract:
BACKGROUND The results of total knee arthroplasty (TKA) in patients with inherited bleeding disorders (IBDs) are poorer when compared with those in the general population, with a notably higher risk of complications and higher revision rates. Thus, revision procedures are becoming a growing concern in this group of patients. The aim of this study was to evaluate the results of revision TKA in patients with IBD. MATERIAL AND METHODS A retrospective cohort study with longitudinal assessment of hemophilia patients scheduled for revision TKA between January 2010 and September 2015 was performed. The clinical status of the patients was assessed based on the Knee Society Score, and the Numeric Rating Scale was used to assess knee pain severity and patient satisfaction with the surgery. Radiological examination, post-operative complications, and reinterventions were recorded and analyzed. RESULTS Very good results were obtained in all patients treated for aseptic loosening of the implant. However, inferior results were found in cases with infection. All patients operated on for aseptic loosening required only single-stage TKA, whereas patients with infection underwent multiple interventions. Complications were observed only in cases with infection. CONCLUSIONS Our study clearly outlined the differences in results based on failure mode, with far inferior results obtained in cases with infection. Given the lack of data in this area as well as the high specificity of this population, further high-quality studies are needed.
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