Related Experiment Video
Updated: Mar 9, 2026

04:25
A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
Published on: April 28, 2022
2.3K
Avoiding Chlorhexidine Burns in Preterm Infants
Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
|January 10, 2017
Summary
Chlorhexidine, a skin antiseptic, can cause severe chemical burns in preterm infants. New safety labeling addresses this risk, offering guidance for safer use in neonatal intensive care units (NICUs) to prevent newborn injuries.
Area of Science:
- Neonatal care
- Dermatology
- Pharmacology
Background:
- Chlorhexidine is a widely used skin antiseptic in neonatal intensive care units (NICUs).
- Off-label use of chlorhexidine is common in NICUs for various indications.
- Recent safety labeling changes highlight the risk of severe chemical burns in preterm infants.
Purpose of the Study:
- To inform healthcare professionals about the risks associated with chlorhexidine use in neonates.
- To provide practical recommendations for the safe application of chlorhexidine in NICUs.
- To guide clinicians in preventing chlorhexidine-induced chemical burns in newborns.
Main Methods:
- Review of recent safety labeling updates for chlorhexidine.
- Analysis of reported adverse events related to chlorhexidine in preterm infants.
- Development of evidence-based guidelines for safe use.
Main Results:
- Chlorhexidine can cause severe chemical burns, particularly in vulnerable preterm infants.
- Updated safety information emphasizes the need for cautious application.
- Specific protocols are necessary to mitigate burn risks.
Conclusions:
- Adherence to updated safety guidelines is crucial for preventing chlorhexidine-related injuries.
- Implementing standardized safe-use practices can protect newborns from chemical burns.
- Healthcare providers should be aware of the risks and protective measures when using chlorhexidine in NICUs.
Related Concept Videos
Hand hygiene
6.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
6.4K
Burn Injuries
4.9K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.9K
Pharmacokinetics in Pediatric Patients: Drug Excretion
343
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
343
Depolarizing Blockers: Pharmocokinetics
685
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
685
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
586
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
586

