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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Membrane Adhesion through Bridging by Multimeric Ligands.

Omar A Amjad1, Bortolo M Mognetti2, Pietro Cicuta1

  • 1Biological and Soft Systems, Cavendish Laboratory, University of Cambridge , JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 11, 2017
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Summary
This summary is machine-generated.

Multivalent ligand-receptor interactions drive lipid vesicle adhesion to supported bilayers within a specific concentration range. This study reveals optimal conditions for vesicle binding, crucial for developing advanced biosensing technologies.

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Area of Science:

  • Biophysics
  • Materials Science
  • Biochemistry

Background:

  • Multivalent ligand-receptor interactions are key for self-assembly in various systems.
  • Deformable liposomes exhibit morphological changes based on ligand concentration.
  • Previous work explored self-assembly with nanoparticles and colloids.

Purpose of the Study:

  • To investigate a biosensing system using lipid vesicles and supported lipid bilayers.
  • To characterize vesicle adhesion driven by multivalent streptavidin (SA) bridging.
  • To understand the role of ligand concentration on vesicle morphology and adhesion dynamics.

Main Methods:

  • Utilized lipid vesicles and supported lipid bilayers functionalized with biotinylated receptors.
  • Employed multivalent streptavidin (SA) as the bridging ligand.
  • Analyzed vesicle adhesion, morphological changes, membrane tension, and bridge kinetics at varying SA concentrations.
  • Developed a theoretical model to explain adhesion mechanisms.

Main Results:

  • Vesicle adhesion was observed only within a specific range of SA concentrations.
  • Neither very low nor very high SA concentrations supported adhesion.
  • Characterized stable adhesion patch formation, membrane tension, and bridge dynamics.
  • A theoretical model elucidated the role of SA multivalency in adhesion onset.

Conclusions:

  • Lipid vesicle adhesion to supported bilayers is a tunable process dependent on ligand concentration.
  • The findings provide insights into multivalent interactions for designing biosensors.
  • This research could inform the development of next-generation biomolecular analytical devices.