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PPARs modulate cardiac metabolism and mitochondrial function in diabetes.

Ting-Wei Lee1,2, Kuan-Jen Bai3,4, Ting-I Lee2,5

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Xing Street, Taipei, 11031, Taiwan.

Journal of Biomedical Science
|January 11, 2017
PubMed
Summary

Diabetic cardiomyopathy, a complication of diabetes mellitus, involves mitochondrial dysfunction. Targeting peroxisome proliferator-activated receptors (PPARs) may offer a treatment strategy, but their cardiovascular effects require further study.

Keywords:
CardiomyopathyDiabetes mellitusMetabolismMitochondriaPeroxisome proliferator-activated receptors

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Area of Science:

  • Cardiovascular Science
  • Metabolic Disease Research
  • Mitochondrial Biology

Background:

  • Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus (DM), with limited effective treatments.
  • Mitochondrial dysfunction is a key factor in the development of DCM.
  • Peroxisome proliferator-activated receptors (PPARs) regulate metabolic homeostasis and mitochondrial function.

Purpose of the Study:

  • To review the current understanding of the dual effects of PPARs on mitochondria in the context of diabetic hearts.
  • To explore metabolic regulation strategies targeting mitochondrial dysfunction for DCM treatment.

Main Methods:

  • Literature review of studies investigating PPARs, mitochondrial function, and diabetic cardiomyopathy.
  • Analysis of research on the beneficial and detrimental impacts of PPARs in diabetic cardiac conditions.

Main Results:

  • PPARs play a complex role in regulating glucose and lipid metabolism, impacting cardiac mitochondria.
  • Synthetic PPAR agonists have shown mixed results regarding cardiovascular effects in diabetes.
  • Evidence suggests both protective and harmful influences of PPARs on mitochondrial function in diabetic hearts.

Conclusions:

  • Targeting mitochondrial dysfunction via metabolic regulation is a promising avenue for DCM treatment.
  • The precise role of PPARs in diabetic cardiomyopathy requires further elucidation due to controversial cardiovascular effects.
  • Understanding the nuanced effects of PPARs on cardiac mitochondria is crucial for developing effective therapies.