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Clinical Imaging of Microwave Mammography

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Published on: November 14, 2025

Benign breast lesions that mimic malignancy.

Vanda F Torous¹, Stuart J Schnitt¹, Laura C Collins¹

¹Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

|January 11, 2017

Summary

This summary is machine-generated.

Many benign breast lesions mimic cancer, posing diagnostic challenges for pathologists. This review details key features, pitfalls, and diagnostic strategies for these challenging breast conditions.

Keywords:

Benign breast lesions Toker cells benign lymph node inclusions collagenous spherulosis displaced epithelium epithelioid myofibroblastoma granular cell tumour mucocele-like lesion

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Area of Science:

Pathology
Oncology
Breast Imaging

Background:

Benign breast lesions frequently exhibit morphological similarities to malignant counterparts.
Accurate diagnosis of breast lesions is crucial for appropriate patient management and treatment.
Diagnostic challenges arise from overlapping features between benign and malignant breast conditions.

Purpose of the Study:

To review benign breast lesions that mimic malignant entities.
To highlight key morphological and immunohistochemical features of these mimics.
To outline diagnostic approaches and potential pitfalls for pathologists.

Main Methods:

Literature review of benign breast lesions with malignant potential.
Analysis of morphological and immunohistochemical characteristics.
Discussion of diagnostic strategies and differential diagnoses.

Main Results:

Several benign breast lesions were identified as common mimics of malignancy.
Specific morphological and immunohistochemical markers were associated with each mimic.
Diagnostic pitfalls and their resolutions were elucidated.

Conclusions:

Recognizing benign breast mimics is essential for accurate pathological diagnosis.
Careful evaluation of morphological and immunohistochemical data aids in differentiating mimics from malignancy.
This review provides a framework for pathologists to confidently diagnose challenging benign breast lesions.