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Influence of brachytherapy (192Ir afterloading) on cell-mediated immune reactions in patients with stage I
G J Gerstner1, H Kucera, S Kudlacek
1Department of Gynecological Radiotherapy, Vienna University Medical School, Austria.
Abstract:
The influence of radiation therapy on cell-mediated immune reactions in cancer patients seems to depend on source, dose, and area of irradiation, as well as on the variables reflected by the patient population investigated. In the present study we demonstrated that brachytherapy (192Ir afterloading), applied to patients with inoperable stage I endometrial cancer, has no immediate or sustained effect on lymphocyte function. Both lymphocyte mitogen response and natural killer cell (NK) activity are not significantly changed in terms of baseline values compared with test results during and after therapy. Brachytherapy, as used in this study, has no influence on cell-mediated immunity in patients with endometrial cancer stage I.