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The Generation R Study: design and cohort update 2017.

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The Generation R Study tracks children from fetal life to adulthood, identifying early environmental and genetic factors influencing health and development. This research aims to optimize health strategies for mothers and children.

Keywords:
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Area of Science:

  • Pediatrics
  • Developmental Biology
  • Public Health

Background:

  • The Generation R Study is a large-scale, population-based prospective cohort study.
  • It follows participants from fetal life through young adulthood.

Purpose of the Study:

  • To identify early environmental and genetic determinants of normal and abnormal growth and development.
  • To understand causal pathways affecting child and maternal health outcomes.

Main Methods:

  • Prospective cohort design with data collection from fetal life to age 10 years.
  • Multidisciplinary approach including questionnaires, physical examinations, imaging, and biological sampling.
  • Genome-wide and epigenome-wide association screens available for analysis.

Main Results:

  • Baseline enrollment of 9778 mothers between April 2002 and January 2006.
  • Baseline response rate of 61% with follow-up rates around 80% until age 10.
  • Comprehensive data on exposures (environmental, genetic, lifestyle, nutritional) and health outcomes (behavior, cognition, physical development, immunity, etc.).

Conclusions:

  • Results contribute to developing strategies for optimizing health and healthcare for pregnant women and children.
  • Provides insights into early life origins of health and disease.