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Corrigendum: Epileptiform activity in the mouse visual cortex interferes with cortical processing in connected areas.

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Epileptiform activity in the mouse visual cortex interferes with cortical processing in connected areas.

L Petrucco¹, E Pracucci¹, M Brondi¹

¹NEST, Istituto Nanoscienze CNR and Scuola Normale Superiore Pisa, Pisa, Italy.

Scientific Reports

|January 11, 2017

Summary

This summary is machine-generated.

Hypersynchronous interictal spikes (ISs) disrupt brain function even without seizures. This study shows focal ISs impair visual processing in connected brain areas, impacting information processing.

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Last Updated: Mar 9, 2026

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Published on: May 15, 2018

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Area of Science:

Neuroscience
Epilepsy Research
Cognitive Function

Background:

Epileptiform activity, characterized by interictal spikes (ISs), is linked to cognitive deficits.
Clinical observations suggest ISs may directly cause cognitive impairment, independent of the underlying epilepsy cause.

Purpose of the Study:

To investigate if focal interictal spikes (ISs) disrupt neuronal processing in brain regions not directly involved in the epileptic activity.
To understand the impact of ISs on information processing in connected cortical areas.

Main Methods:

Induction of focal ISs in the visual cortex of anesthetized mice.
Analysis of local field potentials and neuronal firing probability.
Assessment of visual processing alterations relative to IS and stimulus timing.

Main Results:

Focal ISs subtly disrupted local field potentials in the contralateral hemisphere, even without direct invasion.
Neuronal firing probability was modulated by contralateral IS activity.
Visual processing was altered based on the temporal relationship between ISs and stimulus presentation.

Conclusions:

Focal interictal spikes (ISs) impact brain dynamics beyond the epileptic focus.
ISs disrupt normal cortical rhythms and affect information processing in connected areas.
This suggests ISs interfere with cognitive functions through widespread neural network disruption.