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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Molecularly Imprinted Biodegradable Nanoparticles.

Mariacristina Gagliardi¹, Alice Bertero^2,3, Angelo Bifone²

¹Istituto Italiano di Tecnologia, Center for Micro Bio-Robotics @SSSA, viale Rinaldo Piaggio,34, 56025, Pontedera, Italy.

Scientific Reports

|January 11, 2017

Summary

This summary is machine-generated.

Researchers developed novel biodegradable molecularly imprinted nanoparticles using poly(lactide-co-glycolide) (PLGA). These nanoparticles show enhanced binding and cell uptake, advancing targeted drug delivery in nanomedicine.

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Area of Science:

Nanomedicine
Polymer Chemistry
Biomaterials Science

Background:

Biodegradable polymer nanoparticles are key for targeted drug delivery.
Molecular imprinting offers specific targeting but requires rigid structures, challenging for biodegradable polymers.
Fully biodegradable molecularly imprinted particles have not been previously reported.

Purpose of the Study:

To synthesize novel, fully biodegradable molecularly imprinted nanoparticles.
To combine biodegradability with molecular recognition capabilities for enhanced drug delivery.
To overcome limitations of rigid structures in traditional molecular imprinting.

Main Methods:

Synthesized a novel biodegradable cross-linker via ring-opening polymerization of glycolide and lactide.
Functionalized the macromer with end-groups for nanoparticle synthesis.
Created narrowly-dispersed nanoparticles using poly(lactide-co-glycolide) (PLGA), acrylic acid, and biotin as a template molecule via radical polymerization.

Main Results:

Achieved narrowly-dispersed nanoparticles with combined biodegradability and molecular recognition.
Demonstrated a twentyfold increase in binding capacity for biotin and biotinylated bovine serum albumin compared to non-imprinted nanoparticles.
Confirmed effective biotin-mediated cell internalization through in vitro degradation and cell culture tests.

Conclusions:

Successfully synthesized the first fully biodegradable molecularly imprinted nanoparticles.
These novel nanoparticles exhibit superior binding affinity and targeted cellular uptake.
The developed nanocarriers hold significant potential for advanced nanomedicine and drug delivery applications.