Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dense Connective Tissue01:13

Dense Connective Tissue

13.5K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
13.5K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

93.7K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
93.7K
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

22.2K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
22.2K
Overview of Muscle Tissues01:25

Overview of Muscle Tissues

25.0K
The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
25.0K
Introduction to the Skeletal System01:20

Introduction to the Skeletal System

10.3K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
10.3K
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

3.3K
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of morbidity, multimorbidity, and mortality in aging cats: findings from seven years of the Cat Prospective Ageing and Welfare Study.

Frontiers in veterinary science·2026
Same author

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
Same author

Time-restricted feeding enhances cross-tissue temporal coordination of mitochondrial-associated transcripts.

iScience·2026
Same author

Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.

Sports medicine (Auckland, N.Z.)·2026
Same author

CTRP10 is required for optimal motor function.

The Journal of biological chemistry·2026
Same author

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Mar 9, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.2K

Sex differences in tendon structure and function.

Dylan C Sarver1, Yalda Ashraf Kharaz2, Kristoffer B Sugg1,3,4

  • 1Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|January 11, 2017
PubMed
Summary
This summary is machine-generated.

Male and female mouse tendons show similar mechanical properties and composition, despite size differences. Female tendons exhibit slightly higher levels of certain extracellular matrix proteins.

Keywords:
mechanicsproteomicssextendontranscriptomics

More Related Videos

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K
Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
07:50

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Published on: January 27, 2023

3.8K

Related Experiment Videos

Last Updated: Mar 9, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.2K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K
Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
07:50

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Published on: January 27, 2023

3.8K

Area of Science:

  • Musculoskeletal research
  • Orthopaedic research
  • Tendon biology

Background:

  • Chronic tendon injuries cause significant musculoskeletal disability.
  • Sex-based differences in tendon structure and function are poorly understood.

Purpose of the Study:

  • To investigate sex-based differences in mouse tendon mechanical properties, biochemical composition, transcriptome, and cellular activity.
  • Evaluate how sex influences tendon extracellular matrix (ECM) and cellular behavior.

Main Methods:

  • In vitro biomechanics, mass spectrometry-based proteomics, and genome-wide expression profiling were used.
  • Cell culture techniques assessed fibroblast behavior in sex-specific serum and ECM.

Main Results:

  • Male tendons were larger, but cell density was higher in females.
  • No significant differences in plantaris tendon mechanical properties were found.
  • Female tendons showed increased fibronectin, periostin, and tenascin C, with minimal transcriptome differences.

Conclusions:

  • Male and female mouse tendons exhibit largely similar mechanical properties and ECM composition.
  • Minor increases in specific ECM proteins in female tendons warrant further investigation.
  • Sex does not profoundly affect tendon fibroblast gene expression in vitro.