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Updated: Mar 9, 2026

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Warfarin-induced tissue necrosis: a case study.

Heather Fisher1, Grace Leedham2

  • 1Windermere and Bowness Medical Practice, Cumbria.

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|January 11, 2017
PubMed
Summary
This summary is machine-generated.

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Warfarin-induced tissue necrosis is a rare but serious adverse drug reaction. Early diagnosis and prompt treatment are crucial for managing this complication and preventing severe outcomes.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Adverse Drug Reactions

Background:

  • Warfarin is an anticoagulant medication with a narrow therapeutic index.
  • Tissue necrosis is a rare but severe adverse drug reaction associated with warfarin therapy.
  • Recognizing and managing this complication is vital for patient safety.

Purpose of the Study:

  • To highlight the importance of recognizing warfarin-induced tissue necrosis.
  • To emphasize the need for prompt diagnosis and management of this adverse drug reaction.
  • To underscore the role of nurse prescribers in identifying and acting upon adverse drug events.

Main Methods:

  • A clinical case study of a patient experiencing warfarin-induced tissue necrosis was presented.
  • The case illustrates the clinical presentation and management challenges.
Keywords:
Adverse drug reactionsanticoagulationnurse prescribingtissue necrosiswarfarinwound care

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  • Review of clinical practice and literature on adverse drug reactions.

    • Main Results:

    • The case study demonstrated the potential for severe tissue damage from warfarin.
    • Timely intervention was critical in managing the patient's condition.
    • The importance of prescriber awareness of potential adverse drug reactions was reinforced.

    Conclusions:

    • Warfarin-induced tissue necrosis requires vigilant monitoring and prompt clinical action.
    • Nurse prescribers play a key role in the safe management of warfarin therapy.
    • Awareness and preparedness for adverse drug reactions are essential for all healthcare providers.