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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Assessment of subclinical left ventricular changes in essential hypertensive patients with hyperuricemia: A

Xiaoyan Fang1, Cuizhen Pan1, Yongle Chen1

  • 1a Department of Echocardiography , Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging , Shanghai , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 11, 2017
PubMed

Insights

Hyperuricemia (HU) worsens left ventricular (LV) function and structure in hypertension patients, detectable by 3D speckle-tracking echocardiography (3DSTE). Lowering uric acid may benefit these patients.

Area of Science:

  • Cardiology
  • Echocardiography
  • Hypertension Research

Background:

  • Hyperuricemia (HU) is linked to cardiovascular disease.
  • Subclinical left ventricular (LV) changes in hypertension (HT) are not fully understood.
  • The role of HU in LV remodeling in HT requires further investigation.

Purpose of the Study:

  • To assess HU's impact on subclinical LV function and structure in HT patients using 3D speckle-tracking echocardiography (3DSTE).
  • To explore correlations between serum uric acid (SUA) levels and 3DSTE parameters in hypertensive and nonhypertensive patients with HU.

Main Methods:

  • Four age- and sex-matched groups were studied: controls, HT-HU+, HT+HU-, and HT+HU+.
  • Conventional echocardiography and 3DSTE were performed to assess LV function and structure.
  • Serum uric acid (SUA) levels, LV volumes, ejection fraction (EF), LV mass index (LVMi-3D), global longitudinal strain (GLS), and global circumferential strain (GCS) were analyzed.

Main Results:

  • LV volumes and EF were similar across groups, but GLS decreased and LVMi-3D increased progressively from controls to patients with both HU and HT.
  • Significant correlations were found between SUA levels and both reduced GLS (r = -0.461) and increased LVMi-3D (r = 0.504) in patients with HU.
  • These findings suggest HU contributes to LV dysfunction and remodeling.

Conclusions:

  • Hyperuricemia may accelerate LV systolic dysfunction and remodeling in hypertensive individuals.
  • 3DSTE can detect these subclinical cardiac changes.
  • Early uric acid-lowering therapy could be beneficial for hypertensive patients with HU.
Abstract

Keywords:
Hypertensionhyperuricemialeft ventricularspeckle-trackingthree-dimensional

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