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The significance of microRNAs in the course of rDD

Kinga Bobińska1, Janusz Szemraj2, Joanna Mossakowska-Wójcik1

  • 1Department of Adult Psychiatry, Medical University of Lodz, Łódź, Poland.

Pharmacological Reports : PR
|January 11, 2017
PubMed
Abstract

Insights

MicroRNAs (miRNAs) show distinct expression patterns between depressed patients and healthy individuals. However, no significant differences were found in miRNA expression between first-episode depression and recurrent depressive disorder patients.

Area of Science:

  • Genetics
  • Neuroscience
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their role in the development of various diseases, including mental disorders.
  • Specific miRNAs (miRNA-370, miRNA-411, miRNA-433, miRNA-487b, and miRNA-539) were selected for their potential involvement in the etiology and progression of recurrent depressive disorders.

Purpose of the Study:

  • To investigate the differential expression of selected miRNAs in patients with recurrent depressive disorders compared to those experiencing their first depressive episode.
  • To explore the relationship between miRNA expression levels and the number of depressive episodes or severity of depressive disorders.
  • To compare miRNA expression profiles between individuals with depressive symptoms and a healthy control group.

Main Methods:

  • A study population comprising 138 patients with depression and 95 healthy controls was analyzed.
  • Depressed patients were categorized into two subgroups: first depressive episode (ED-I) and recurrent depressive disorder (rDD).
  • Expression levels of specific miRNAs were quantified and compared between groups.

Main Results:

  • No statistically significant differences in the expression of selected miRNAs were observed between the ED-I and rDD patient groups.
  • No significant correlation was found between the number of depression episodes, depressive disorder severity, and the expression of the studied miRNAs.
  • Statistically significant differences in the expression of analyzed variables were identified between individuals with depressive symptoms and healthy controls.

Conclusions:

  • MiRNA expression does not differ significantly between patients with recurrent depressive disorders and those with a first episode of depression.
  • Confirmed significant differences in the expression of analyzed variables between individuals with depressive symptoms and healthy controls, highlighting the potential role of miRNAs in depression.
  • The findings suggest that while miRNAs may be implicated in the general pathophysiology of depression, they do not appear to differentiate between the early and later stages of recurrent depressive disorder.
Keywords:
DepressionExpressionFirst episodeRecurrent depressive disordermicroRNAs

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