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Related Experiment Videos

Chloroquine phosphate induced haematemesis.

D K Bhasin1, R S Chhina

  • 1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Human Toxicology
|September 1, 1989
PubMed
Summary

Two patients experienced upper gastrointestinal bleeding, specifically haematemesis, after taking chloroquine phosphate. Endoscopy revealed stomach and duodenal erosions, indicating potential gastrointestinal toxicity from the drug.

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Toxicology

Background:

  • Chloroquine phosphate is an antimalarial drug with known potential side effects.
  • Gastrointestinal adverse events associated with chloroquine are less commonly reported but can be serious.

Observation:

  • Two distinct cases of haematemesis (vomiting blood) are presented.
  • The onset of symptoms occurred 30 and 36 hours post-ingestion of chloroquine phosphate.

Findings:

  • Upper gastrointestinal endoscopy revealed significant erosions in the stomach.
  • Duodenal erosions were also observed in both patients following chloroquine phosphate intake.

Implications:

  • These cases highlight the potential for chloroquine phosphate to cause upper gastrointestinal mucosal damage.
  • Clinicians should be aware of the risk of gastrointestinal complications, including erosions and bleeding, with chloroquine use.
  • Further investigation into the mechanisms of chloroquine-induced gastroduodenal toxicity may be warranted.

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