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Published on: December 11, 2016
Characterizing Pharmacogenomic-Guided Medication Use With a Clinical Data Repository.
P C Mathias1, N Hendrix2, W-J Wang2
1Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Pharmacogenomic testing is rarely used in clinical practice without structured programs. This study found low uptake of germline and somatic pharmacogenomic tests, highlighting the need for organized approaches to precision medicine.
Area of Science:
- Clinical Pharmacology
- Genomics
- Health Services Research
Background:
- Pharmacogenomic-guided medication use is key to precision medicine.
- Adoption rates in healthcare systems are not well-understood.
- This study examines pharmacogenomic testing frequency in a system without a structured program.
Purpose of the Study:
- To determine the frequency of pharmacogenomic testing in a large health system.
- To assess the uptake of germline and somatic pharmacogenomic tests.
- To evaluate the need for structured pharmacogenomic testing programs.
Main Methods:
- Utilized a multisite clinical data repository.
- Identified adult patients' first medication orders (Jan 2011-Dec 2013).
- Investigated germline and somatic pharmacogenomic testing frequency based on FDA label information and Pharmacogenomics Knowledgebase levels.
Main Results:
- 1.5% of medication orders with recommended/required germline pharmacogenomic testing showed detectable testing.
- 20% of medication orders with required somatic pharmacogenomic testing showed detectable testing.
- Overall pharmacogenomic testing rates were low.
Conclusions:
- Low rates of pharmacogenomic testing indicate limited adoption.
- Structured pharmacogenomic testing programs are essential for advancing precision medicine.
- Systematic implementation is necessary to realize the benefits of pharmacogenomics.
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