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Suppression of anaphylactic shock in sensitized guinea pigs by cytochalasin B
D V Stefani1, Veltishchev YuE, A V Semyonov
1Moscow Research Institute of Pediatrics and Pediatric Surgery, Ministry of Health of the Russian Soviet Federated Socialist Republic.
Immunology Letters
|September 1, 1989
Abstract:
Twenty-three guinea pigs, presensitized with horse serum, were injected intracardially with 1 ml of 1.5 X 10(-4) M cytochalasin B in a 2.5% dimethyl sulfoxide solution, 1.5 h before being challenged with the serum. Eighteen of the guinea pigs (80%) survived. A single intracardiac injection of cytochalasin B to the control group of guinea pigs at 1.5 h before administration of the allergen did not prevent their sensitization and death following challenge.