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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Related Experiment Video

Updated: Mar 9, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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Tumors block pain with CXCL12.

Nancy R Gough1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|January 12, 2017
PubMed
Summary

Early pancreatic cancer releases the chemokine CXCL12, which attracts Schwann cells. This interaction effectively suppresses pain signaling associated with the cancer.

Area of Science:

  • Oncology
  • Neuroscience
  • Cell Biology

Background:

  • Pancreatic cancer is a complex disease often associated with significant pain.
  • The tumor microenvironment plays a crucial role in cancer progression and symptomology.
  • Chemokines are signaling proteins with diverse roles in inflammation, immunity, and cell trafficking.

Purpose of the Study:

  • To investigate the role of the chemokine CXCL12 in early-stage pancreatic cancer.
  • To determine the interaction between CXCL12 and Schwann cells in the context of pancreatic cancer.
  • To elucidate the mechanism by which CXCL12 influences pain signaling in pancreatic cancer.

Main Methods:

  • Analysis of chemokine expression in early-stage pancreatic tumor samples.
  • In vitro co-culture systems of pancreatic cancer cells and Schwann cells.

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  • Assessment of pain signaling pathways using molecular and electrophysiological techniques.

    • Main Results:

    • Elevated levels of the chemokine CXCL12 were detected in early-stage pancreatic tumors.
    • CXCL12 secreted by cancer cells was found to recruit Schwann cells to the tumor vicinity.
    • Recruitment of Schwann cells by CXCL12 led to the suppression of neuronal pain signaling.

    Conclusions:

    • CXCL12 is a key mediator in the early stages of pancreatic cancer, influencing the tumor microenvironment.
    • The recruitment of Schwann cells by CXCL12 represents a novel mechanism for pain modulation in pancreatic cancer.
    • Targeting the CXCL12-Schwann cell axis may offer therapeutic strategies for managing pain in pancreatic cancer patients.