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Herpetic cervicitis--a histo-morphologic study.

S Shariff, J A Thomas

    Indian Journal of Pathology & Microbiology
    |April 1, 1989
    PubMed
    Summary
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    Herpetic cervicitis affects 19% of routine cervical biopsies, with distinct morphological changes observed. This study categorizes these changes and confirms the Herpes virus presence using specialized stains.

    Area of Science:

    • Gynecologic pathology
    • Virology
    • Histopathology

    Background:

    • Herpetic cervicitis is a condition affecting the cervix uteri.
    • Understanding its prevalence and morphological characteristics is crucial for diagnosis.

    Purpose of the Study:

    • To determine the prevalence of herpetic cervicitis in cervical biopsies.
    • To classify the morphological changes associated with herpetic cervicitis.
    • To investigate the evolution of these histological changes.

    Main Methods:

    • Histological examination of 879 human uterine cervices over 51 months.
    • Classification of lesions into types A-D based on morphological progression.
    • Confirmation of Herpes virus using Peroxidase-Antiperoxidase stain.

    Related Experiment Videos

  • Study of bullae evolution using Alcian Blue-Periodic Acid Schiff, Methyl Green-Pyronine, and Reticulum stains.

    • Main Results:

    • Herpetic cervicitis was identified in 19% (168/879) of examined cervical biopsies.
    • A grading system (Type A-D) was established, detailing changes from nuclear homogenization to ulceration.
    • Type D lesions exhibited combined A-C changes, submucosal hemorrhages, and severe congestion.
    • Staining confirmed Herpes virus presence and elucidated bullae development.

    Conclusions:

    • Herpetic cervicitis has a significant prevalence in routine cervical biopsies.
    • Morphological criteria can effectively categorize the disease spectrum.
    • Advanced staining techniques aid in viral confirmation and understanding disease progression.