Imaging and T₂ relaxometry of short-T₂ connective tissues in the knee using ultrashort echo-time double-echo...

To develop a radial, double-echo steady-state (DESS) sequence with ultra-short echo-time (UTE) capabilities for T₂ measurement of short-T₂ tissues along with simultaneous rapid, signal-to-noise ratio (SNR)-efficient, and high-isotropic-resolution morphological knee imaging.

THe 3D radial UTE readouts were incorporated into DESS, termed UTEDESS. Multiple-echo-time UTEDESS was used for performing T₂ relaxometry for short-T₂ tendons, ligaments, and menisci; and for Dixon water-fat imaging. In vivo T₂ estimate repeatability and SNR efficiency for UTEDESS and Cartesian DESS were compared. The impact of coil combination methods on short-T₂ measurements was evaluated by means of simulations. UTEDESS T₂ measurements were compared with T₂ measurements from Cartesian DESS, multi-echo spin-echo (MESE), and fast spin-echo (FSE).

UTEDESS produced isotropic resolution images with high SNR efficiency in all short-T₂ tissues. Simulations and experiments demonstrated that sum-of-squares coil combinations overestimated short-T₂ measurements. UTEDESS measurements of meniscal T₂ were comparable to DESS, MESE, and FSE measurements while the tendon and ligament measurements were less biased than those from Cartesian DESS. Average UTEDESS T₂ repeatability variation was under 10% in all tissues.

The T₂ measurements of short-T₂ tissues and high-resolution morphological imaging provided by UTEDESS makes it promising for studying the whole knee, both in routine clinical examinations and longitudinal studies. Magn Reson Med 78:2136-2148, 2017. © 2017 International Society for Magnetic Resonance in Medicine.