Database of Optimized Proteomic Quantitative Methods for Human Drug Disposition-Related Proteins for Applications in

M Vrana1, D Whittington2, V Nautiyal3

  • 1Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

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The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
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