Characterization and application of a self-aspirating electrospray source with pneumatic-assisted ionization.

Area of Science:

• Analytical Chemistry
• Mass Spectrometry Instrumentation

Background:

• Ambient mass spectrometry requires versatile ion sources for direct sample analysis.
• Existing electrospray ionization sources often lack self-aspiration capabilities or simplified designs.

Purpose of the Study:

• To introduce a novel gas-assisted electrospray ion source for ambient mass spectrometry.
• To demonstrate simultaneous self-aspiration and electrospray capabilities.
• To optimize the spray module through gas dynamic studies.

Main Methods:

• Development of a single gas-assisted electrospray ion source with a mini air pump for sheath gas flow.
• Gas dynamic study for structural optimization of the spray module.
• Systematic characterization via simulated and experimental investigations.

Main Results:

• The ion source achieved simultaneous self-aspiration and electrospray.
• Demonstrated satisfactory stability and quantitative operation in electrospray ionization mass spectrometry.
• Successfully operated as a desorption electrospray ionization source for solid samples.

Conclusions:

• The developed ion source provides a practical and versatile approach for ambient mass spectrometry.
• Its simplified design and self-aspirating capability allow for unrestricted sampling.
• The gas dynamic studies contribute to the development of future self-aspirating spray devices.