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Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...

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Related Experiment Video

Updated: Mar 9, 2026

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Published on: November 30, 2017

Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex.

Bartosz Teleńczuk¹, Nima Dehghani^2,3, Michel Le Van Quyen⁴

¹Unité de Neurosciences, Information &Complexité, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France.

Scientific Reports

|January 12, 2017

Summary

The local field potential (LFP) reflects primarily inhibitory neuron activity in the human and monkey neocortex. Researchers used spike-triggered LFP averages to characterize the unitary contribution of single neurons to the LFP signal.

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Last Updated: Mar 9, 2026

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

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Published on: November 30, 2017

Simultaneous Recordings of Cortical Local Field Potentials and Electrocorticograms in Response to Nociceptive Laser Stimuli from Freely Moving Rats

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Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

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Published on: July 1, 2018

Area of Science:

Neuroscience
Computational Neuroscience

Background:

The local field potential (LFP) is generated by neuronal populations, but the contribution of individual spiking neurons remains unclear.
Understanding single-neuron contributions to LFP is crucial for interpreting neural activity.

Purpose of the Study:

To investigate the unitary contribution of spiking neurons to the local field potential (LFP) in the human and monkey neocortex.
To characterize the spatial and temporal properties of spike-triggered LFP averages (st-LFPs).

Main Methods:

Multi-electrode array recordings from human and monkey neocortex.
Analysis of spike-triggered LFP averages (st-LFPs).
Application of a spatial filter to isolate single-spike related LFP components.

Main Results:

Raw st-LFPs were broad due to ongoing activity and network connectivity.
A spatial filter limited st-LFPs to an 800 μm radius, showing axonal propagation speeds.
Inhibitory neuron st-LFPs exhibited shorter latencies compared to excitatory neurons.

Conclusions:

The LFP in human and monkey neocortex primarily reflects inhibitory neuron activity.
Filtered st-LFPs demonstrate the local, unitary nature of single-spike contributions to the LFP.