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A reduced mechanical model for cAMP-modulated gating in HCN channels

Stephanie Weißgraeber1, Andrea Saponaro2, Gerhard Thiel1

  • 1Department of Biology, TU Darmstadt, Germany.

Scientific Reports
|January 12, 2017
PubMed
Summary

We modeled cyclic nucleotide-gated (HCN) channels, revealing a quaternary twist in their cytosolic regions. This motion explains how cAMP binding allosterically modulates channel gating in heart and brain cells.

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