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Angiotropic syringomatous carcinoma.

Eri Katayama¹, Hiroshi Saruta¹, Aya Nanri¹

¹Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Journal of Cutaneous Pathology

|January 12, 2017

Summary

Syringomatous carcinoma (SC), a rare skin cancer, presented atypically on the sole of an 83-year-old female. This case introduces "angiotropic SC" due to tumor cells invading vessel walls without intravasation.

Keywords:

angiotropic syringomatous carcinoma intraneural invasion microcystic adnexal carcinoma sole vascular wall invasion

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Syringomatous carcinoma (SC) is a rare, slow-growing malignant skin tumor typically affecting the face or scalp.
Understanding rare presentations and histopathological variants is crucial for accurate diagnosis and treatment.

Observation:

An 83-year-old female presented with syringomatous carcinoma on the sole, an exceptionally rare location for this tumor.
Histopathology revealed numerous ducts and cysts in the upper dermis, with cords, strands, and nests in deeper tissues.

Findings:

The tumor exhibited perineural, intraneural, and vascular wall invasion.
Tumor cells invaded vessel walls without intravasation or endothelial interruption, leading to the novel term 'angiotropic SC'.
Extensive local invasion by tumor cells was noted.

Implications:

This case expands the known clinical and histopathological spectrum of syringomatous carcinoma.
The term 'angiotropic SC' may aid in classifying and understanding similar cases with vascular invasion.
Recognizing this rare presentation is vital for appropriate patient management and prognosis.