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The predictive value of Ki-67 before neoadjuvant chemotherapy for breast cancer: a systematic review and
Xianyu Chen1, Chao He1, Dongdong Han2
1Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Aim:
To review the predictive values of Ki-67 before neoadjuvant chemotherapy (NAC) for breast cancer patients.
Methods:
PubMed and EMBASE were searched. Random-effect model meta-analysis was conducted using Revman software.
Results:
High Ki-67 was associated with more pathological complete responses (pCRs) events (odds ratio: 3.10; 95% CI: 2.52-3.81; 53 studies, 10,848 patients) regardless of HR+, HER2+ and triple-negative breast cancer types, the definitions of pCR and cut-off points for Ki-67. Ki-67 could predict pCR in those who received anthracyclines plus taxanes, and anthracyclines only, and those from Asia and Europe.
Conclusion:
High Ki-67 before NAC was a predictor for pCR in neoadjuvant setting for breast cancer patients.
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