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Updated: Mar 9, 2026

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Published on: February 10, 2023
Managing challenging patients with venous thromboembolism: a practical, case-based approach
This review addresses complex venous thromboembolism (VTE) cases, offering guidance on anticoagulation duration for unprovoked VTE and managing cancer-associated VTE. It also covers splanchnic vein thrombosis and thrombolytic therapy for deep vein thrombosis.
Area of Science:
- Clinical Medicine
- Hematology
- Vascular Medicine
Background:
- Venous thromboembolism (VTE) management typically follows established guidelines.
- However, specific clinical scenarios present ongoing management challenges and require further research.
Observation:
- This narrative review focuses on complex VTE cases with less defined treatment pathways.
- Key scenarios include duration of anticoagulation for unprovoked VTE, managing cancer-associated VTE, splanchnic vein thrombosis, and indications for thrombolytic therapy in deep vein thrombosis.
Findings:
- The review provides a case-based approach to these challenging VTE situations.
- It aims to clarify therapeutic strategies where evidence is less robust.
Implications:
- This practical guidance assists clinicians in managing complex VTE patients.
- It highlights areas for future research in anticoagulation and thrombosis treatment.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management
Pulmonary Embolism III: Nursing Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

