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[Enoxacin concentrations in lung tissue].

D Adam1, H Präuer, F Sörgel

  • 1Abteilung für antimikrobielle Therapie und fektionsimmunologie, Universitäts-Kinderklinik, München.

Infection
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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Enoxacin concentrations in lung tissue were approximately three times higher than in serum for patients receiving the antibiotic for bacterial lung infections. This finding is crucial for effective antibiotic treatment strategies.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Respiratory Medicine

Context:

  • Bacterial lung infections require adequate antibiotic concentrations in lung tissue for successful treatment.
  • Enoxacin is an antibiotic used for treating bacterial infections.
  • Pulmonary surgery patients were studied to assess drug penetration into lung tissue.

Purpose:

  • To measure enoxacin concentrations in human lung tissue and serum.
  • To determine the ratio of enoxacin concentrations in lung tissue versus serum.

Summary:

  • Ten patients received 400 mg enoxacin twice daily for three days prior to pulmonary surgery.
  • Eight hours after the final dose, serum and lung tissue samples were collected.
  • Microbiological assay and HPLC revealed mean lung tissue concentrations (6.48-7.41 mg/kg) approximately three times higher than serum concentrations (2.36-2.37 mg/l).

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Impact:

  • Demonstrates favorable enoxacin penetration into lung tissue.
  • Suggests enoxacin may be effective for treating bacterial lung infections.
  • Provides data for optimizing antibiotic dosing regimens in respiratory infections.