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Related Experiment Videos

[Enoxacin concentration in bone tissue].

D Adam1, K Weismeier, F Sörgel

  • 1Abteilung für antimikrobielle Therapie und Infektionsimmunologie, Universitäts-Kinderklinik, München.

Infection
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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Enoxacin concentrations in bone tissue were measured in patients undergoing hip surgery. Results show enoxacin levels in bone exceed those in serum, crucial for treating osteomyelitis.

Area of Science:

  • Pharmacology
  • Orthopedics
  • Infectious Diseases

Context:

  • Bacterial osteomyelitis requires high antibiotic concentrations in bone for effective treatment.
  • Understanding drug distribution in bone tissue is critical for therapeutic success.
  • Enoxacin is a fluoroquinolone antibiotic with potential applications in bone infections.

Purpose:

  • To quantify enoxacin concentrations in human cortical and spongiosa bone tissue.
  • To compare bone enoxacin levels with serum concentrations.
  • To assess the suitability of enoxacin for treating osteomyelitis.

Summary:

  • Enoxacin was administered to ten patients undergoing hip surgery (400 mg b.i.d. for two days).
  • Bone (corticalis and spongiosa) and serum samples were collected 120-210 minutes post-dose.

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  • Mean concentrations: serum 2.88 mg/l, cortical bone 5.90 mg/kg, spongiosa bone 3.95 mg/kg.

    • Impact:

    • Enoxacin achieves significantly higher concentrations in bone tissue compared to serum.
    • These findings support the potential efficacy of enoxacin in treating bacterial osteomyelitis.
    • Provides crucial pharmacokinetic data for enoxacin's use in bone infections.