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Updated: Mar 9, 2026
Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
Stem cells from adipose tissue improve the time of wound healing in rats
Camila Melo Ohashi1, Fabio Alves Morikawa Caldeira1, Denilson José Silva Feitosa-Junior2
1MD, Department of Surgery, Universidade Federal do Pará (UFPA), Belem-PA, Brazil. Technical procedures, acquisition and interpretation of data, manuscript writing.
Purpose::
To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats.
Methods::
Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.
Results::
All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.
Conclusion::
Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
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