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Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
Roberta S Paula1, Vinícius C Souza1, Wilcelly Machado-Silva1
1Universidade de Brasília (UnB), Brasília/DF, Brazil.
Insights
Serum Klotho levels were higher in individuals with a history of myocardial infarction, suggesting Klotho may serve as a potential biomarker for vascular events. Klotho haplotypes showed no significant associations.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Aging Research
Background:
- Vascular diseases cause high mortality globally.
- There is a need for reliable markers to predict major vascular events.
- Klotho is a protein implicated in aging and various diseases.
Purpose of the Study:
- To investigate the association between Klotho haplotypes and serum Klotho levels with vascular event risk factors.
- To explore the relationship between Klotho and a history of vascular events in older adults.
Main Methods:
- Cross-sectional study of 168 older adults.
- Clinical, anthropometric, biochemical, and nutritional assessments.
- Genotyping for Klotho haplotypes (rs9536314, rs9527025) and serum Klotho measurement (ELISA).
Main Results:
- Serum Klotho levels were positively associated with a history of myocardial infarction (p<0.001).
- No significant associations were found between Klotho levels/haplotypes and other classic vascular risk factors (e.g., C-reactive protein, homocysteine).
- Klotho haplotypes did not associate with any of the investigated variables.
Conclusions:
- Elevated serum Klotho levels may indicate a history of myocardial infarction.
- Serum Klotho, but not its haplotypes, shows potential as a biomarker for past myocardial infarction.
- Further research is needed to elucidate Klotho's role in vascular disease pathogenesis.
Objectives::
The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.
Methods::
Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).
Results::
Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context.
Conclusion::
Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
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