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Frontal lobe alterations in schizophrenia: a review
Ateeq Mubarik1, Hassaan Tohid2
1Sindh Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Trends in Psychiatry and Psychotherapy
|January 12, 2017
Summary
Schizophrenia often affects the frontal lobe, causing varied structural and functional brain changes. Further research is needed to fully understand these frontal lobe abnormalities in schizophrenia patients.
Area of Science:
- Neuropsychiatry
- Neuroscience
- Brain Imaging
Background:
- Schizophrenia is a complex psychiatric disorder.
- The frontal lobe is frequently implicated in schizophrenia.
- Variability exists in the extent of frontal lobe alterations among patients.
Purpose of the Study:
- To review and highlight changes in the human frontal lobe in schizophrenia.
- To synthesize current understanding of frontal lobe abnormalities in schizophrenia.
Main Methods:
- Qualitative literature review.
- Analysis of findings from magnetic resonance imaging (MRI) studies.
Main Results:
- Schizophrenia patients show diverse functional, structural, and metabolic frontal lobe abnormalities.
- MRI reveals changes in frontal lobe volume, gray matter, white matter, and activity.
- Underlying mechanisms for these frontal lobe changes remain unclear.
Conclusions:
- The frontal lobe is a key area of interest in schizophrenia research.
- A comprehensive understanding of frontal lobe involvement in schizophrenia is still developing.
- Further research is recommended to elucidate the pathophysiology of schizophrenia-related frontal lobe changes.
