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Riboswitches

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Translational Regulation

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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Related Experiment Video

Updated: Mar 9, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

SnapShot: Non-coding RNAs and Metabolism.

Roxana Simona Redis¹, George Adrian Calin²

¹Departments of Experimental Therapeutics and Leukemia and the Center for RNA Interference and Non-coding RNA, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; ProQR Therapeutics N.V., 2333 CK Leiden, the Netherlands.

Cell Metabolism

|January 12, 2017

Summary

This summary is machine-generated.

Cellular homeostasis is vital for preventing and managing diseases. This study explores how microRNAs and long non-coding RNAs impact metabolic pathways involved in various diseases.

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Metabolic Labeling of Newly Transcribed RNA for High Resolution Gene Expression Profiling of RNA Synthesis, Processing and Decay in Cell Culture

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Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

Cellular homeostasis is increasingly recognized as critical in disease development and progression.
Dysregulation of metabolic pathways is a hallmark of many diseases.
Non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are emerging as key regulators.

Purpose of the Study:

To summarize the role of short microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in metabolic pathways.
To highlight the involvement of these non-coding RNAs in disease initiation and progression.
To provide an overview for scientists and clinicians on this topic.

Main Methods:

Literature review and synthesis of existing research.
Focus on the intersection of non-coding RNA function and metabolic pathways.
Analysis of how altered metabolic pathways in diseases are influenced by miRNAs and lncRNAs.

Main Results:

miRNAs and lncRNAs significantly influence major metabolic pathways.
These non-coding RNAs are implicated in the initiation and progression of various diseases.
Specific examples of miRNA and lncRNA involvement in metabolic dysregulation are discussed.

Conclusions:

Non-coding RNAs are crucial regulators of cellular metabolism.
Targeting miRNAs and lncRNAs presents potential therapeutic strategies for metabolic diseases.
Further research into non-coding RNA-mediated metabolic control is warranted.