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Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function

Xiao Guo1, Natalie M Niemi2, Paul D Hutchins3

  • 1Morgridge Institute for Research, Madison, WI 53715, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

Cell Reports
|January 12, 2017
PubMed
Summary

Mitochondrial phosphatase Ptc7p regulates protein phosphorylation, impacting metabolic homeostasis. Its absence elevates citrate synthase (Cit1p) phosphorylation, reducing TCA cycle activity.

Keywords:
Pptc7Ptc7citrate synthasemitochondriamitochondrial phosphorylationphosphatasephosphoproteomics

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