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Left ventricular wall motion abnormalities are associated with stroke recurrence.

Jeong-Yoon Choi1, Jaehyung Cha1, Jin-Man Jung1

  • 1From the Department of Neurology (J.-Y.C.), Seoul National University College of Medicine, Seoul National University Bundang Hospital; Medical Science Research Center (J.C.) and Department of Neurology (J.-M.J.), Korea University College of Medicine, Korea University Ansan Hospital, Gyeonggi-do; Department of Neurology (W.-K.S.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Neurology (K.O.), Korea University College of Medicine, Korea University Guro Hospital, Seoul; and Department of Neurology (K.-H.C., S.Y.), Korea University College of Medicine, Korea University Anam Hospital, Seoul.

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Summary

Left ventricular wall motion abnormalities (LVWMA) predict stroke recurrence in ischemic stroke patients. Even without high-risk cardioembolic sources, LVWMA independently increases the risk of recurrent stroke.

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Area of Science:

  • Cardiology
  • Neurology
  • Stroke Research

Background:

  • Recurrent stroke poses a significant health burden.
  • Identifying novel risk factors for stroke recurrence is crucial for prevention.
  • Left ventricular wall motion abnormalities (LVWMA) are increasingly recognized in cardiovascular disease.

Purpose of the Study:

  • To determine if left ventricular wall motion abnormalities (LVWMA), independent of high-risk cardioembolic sources, predict stroke recurrence.
  • To evaluate the association between LVWMA and the risk of recurrent ischemic stroke.

Main Methods:

  • A cohort of 4,316 acute ischemic stroke patients was analyzed.
  • Transthoracic echocardiography was used to identify LVWMA.
  • Patients were followed for recurrent stroke events (any stroke and ischemic stroke).

Main Results:

  • Among 430 patients with LVWMA (without high-risk cardioembolic sources), a higher incidence of stroke recurrence was observed.
  • LVWMA were independently associated with an increased risk of both any stroke (HR 1.707) and ischemic stroke (HR 1.709).
  • These associations remained significant after adjusting for traditional risk factors and other clinical variables.

Conclusions:

  • Left ventricular wall motion abnormalities (LVWMA) are an independent predictor of stroke recurrence in ischemic stroke patients.
  • Echocardiographic assessment for LVWMA may aid in risk stratification for secondary stroke prevention.
  • Further research into the mechanisms linking LVWMA to stroke recurrence is warranted.