Related Experiment Video

Updated: Mar 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Biological functions of CDK5 and potential CDK5 targeted clinical treatments

Alison Shupp1, Mathew C Casimiro2, Richard G Pestell2

  • 1Departments of Cancer Biology, Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

Oncotarget
|January 13, 2017
PubMed

Insights

Cyclin-dependent kinase 5 (CDK5) uniquely functions without typical cyclin activation or T-loop phosphorylation. This review explores CDK5

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Biochemistry

Background:

  • Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases crucial for cell cycle regulation.
  • Most CDKs require association with regulatory cyclin subunits and T-loop phosphorylation for activation.
  • CDK5 exhibits unique activation mechanisms, differing from canonical CDK activation pathways.

Purpose of the Study:

  • To review recent findings on molecular interactions regulating CDK5 activity.
  • To discuss CDK5-associated pathways implicated in various diseases.
  • To highlight CDK5's role in tumorigenesis.

Main Methods:

  • Literature review of recent studies on CDK5 molecular interactions.
  • Analysis of evidence linking CDK5 to disease pathways.
  • Synthesis of data on CDK5's role in cancer development.

Main Results:

  • CDK5's activation is independent of canonical cyclin binding and T-loop phosphorylation.
  • CDK5 interacts with various proteins, including cyclins, modulating its activity.
  • Emerging evidence implicates CDK5 in the pathogenesis of diverse diseases, notably cancer.

Conclusions:

  • CDK5 possesses distinct regulatory mechanisms compared to other CDKs.
  • Understanding CDK5's molecular interactions is key to deciphering its role in disease.
  • CDK5 is increasingly recognized as a significant factor in cancer progression.
Keywords:
CDK5cancer

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