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Lactate, a Neglected Factor for Diabetes and Cancer Interaction
Yong Wu1, Yunzhou Dong2, Mohammad Atefi3
1Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA; David Geffen UCLA School of Medicine and UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.
Mediators of Inflammation
|January 13, 2017
Summary
Diabetes and cancer share a link, potentially driven by abnormal lactate metabolism. High lactate levels worsen insulin resistance and cancer malignancy, impacting disease progression.
Area of Science:
- Metabolic signaling in disease pathogenesis
- Oncology and endocrinology research
Background:
- Growing evidence links diabetes and cancer, but underlying mechanisms remain unclear.
- Abnormal lactate metabolism is a shared characteristic of both diabetes and cancer.
- High lactate levels are associated with insulin resistance and increased cancer cell malignancy.
Purpose of the Study:
- To review the role of lactate in the biological characteristics of diabetes and cancer.
- To explore the interactive relationship between diabetes and cancer concerning lactate metabolism.
- To highlight the significance of lactate in the co-occurrence of these diseases.
Main Methods:
- Literature review of existing evidence on lactate's role in diabetes and cancer.
- Analysis of molecular mechanisms linking metabolic remodeling to disease signaling.
- Synthesis of current understanding of diabetes-cancer interactions.
Main Results:
- High lactate production is a key feature in both diabetes and cancer.
- Lactate contributes to insulin resistance and promotes a more aggressive cancer phenotype.
- Abnormal lactate metabolism plays a crucial role in the interplay between diabetes and cancer.
Conclusions:
- Lactate's role in diabetes and cancer interaction warrants further investigation.
- Understanding metabolic remodeling offers potential for novel preventive and therapeutic strategies.
- Targeting lactate metabolism could provide new avenues for treating co-existing diabetes and cancer.
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