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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer

Guoxing Ma1, Mingqing Tang2, Yaqing Wu3

  • 1Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Xiamen Marine and Gene DrugsXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.

American Journal of Translational Research
|January 13, 2017
PubMed

Insights

Noncoding RNAs (ncRNAs) play a crucial role in prostate cancer (PCa) progression, including metastasis and drug resistance. Targeting these ncRNAs may enhance androgen deprivation therapy (ADT) for better treatment of castration-resistant prostate cancer (CRPC).

Area of Science:

  • Oncology and Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • Prostate cancer (PCa) is a leading cause of cancer-related death in men.
  • Androgen receptor (AR) signaling is a key pathway, but noncoding RNAs (ncRNAs) are increasingly recognized for their roles.
  • Aberrant ncRNA expression is linked to PCa progression, including proliferation, metastasis, and drug resistance.

Approach:

  • This review systematically summarizes the known functions of ncRNAs in PCa.
  • It focuses on the multicellular events regulated by ncRNAs.
  • The review provides an overview of potential future research and clinical applications.

Key Points:

  • ncRNAs are critical regulators of prostate cancer cell behavior.
  • Dysregulated ncRNAs contribute to aggressive features and treatment resistance in PCa.
  • Targeting ncRNAs offers a potential strategy to overcome resistance to standard therapies like ADT.

Conclusions:

  • ncRNAs represent promising therapeutic targets in prostate cancer.
  • Combining ncRNA-based strategies with androgen deprivation therapy (ADT) could improve outcomes, particularly for castration-resistant prostate cancer (CRPC).
  • Further research into ncRNA functions and clinical applications is warranted.
Keywords:
Prostate cancerdiagnosislncRNAmiRNAtherapeutic target

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