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Updated: Mar 9, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Immunoglobulin G4-related disease presenting as a pulmonary nodule with an irregular margin
Tetsuyuki Okubo1, Yumiko Oyamada2, Masaya Kawada1
1Department of Thoracic Surgery Tonan Hospital Sapporo Japan.
Abstract:
We report a case of immunoglobulin G4 (IgG4)-related lung disease presenting as a solitary pulmonary nodule with an irregular margin on computed tomography. The nodule showed a high standardized uptake value on positron emission tomography. A malignant pulmonary tumour could not be excluded. Middle lobectomy was performed. Histological analysis revealed marked lymphoplasmacytic infiltration and storiform fibrosis. Immunostaining indicated the presence of IgG4-positive plasma cells. A definitive diagnosis of IgG4-related disease was confirmed.
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