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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Disorders of the Male Reproductive System01:20

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Testosterone replacement in the infertile man.

Ahmad Majzoub1, Edmund Sabanegh1

  • 1Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Translational Andrology and Urology
|January 13, 2017
PubMed
Summary
This summary is machine-generated.

Hypogonadism affects men’s health, but testosterone replacement can impair fertility. Alternative treatments like aromatase inhibitors (AIs) can restore testosterone levels while preserving fertility.

Keywords:
Hypogonadisminfertilitytestosterone replacement

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Area of Science:

  • Endocrinology
  • Men's Health
  • Reproductive Medicine

Background:

  • Hypogonadism is a prevalent condition in men, impacting sexual function, overall health, and well-being.
  • While testosterone (T) supplementation is a common treatment, it can negatively affect testicular function and fertility.
  • There is a need for therapeutic strategies that address hypogonadism symptoms without compromising reproductive capacity.

Approach:

  • Investigating alternative treatments to testosterone supplementation for hypogonadism.
  • Evaluating the efficacy of selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors (AIs).
  • Assessing the potential of these alternatives to stimulate endogenous testosterone production.

Key Points:

  • Alternative treatments can restore serum testosterone levels effectively.
  • Selective estrogen receptor modulators, gonadotropins, and AIs offer a fertility-sparing approach.
  • These methods provide symptomatic relief for hypogonadism patients.

Conclusions:

  • Alternative therapies show promise for managing hypogonadism, particularly in men desiring conception.
  • Aromatase inhibitors (AIs) and other modulators represent a viable strategy for preserving fertility during treatment.
  • Further research into these approaches can optimize hypogonadism management for diverse patient needs.