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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Urodynamic Studies: Uroflowmetry01:19

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Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
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Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

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Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
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Related Experiment Video

Updated: Mar 9, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Testosterone replacement therapy and voiding dysfunction.

Wesley Baas1, Tobias S Köhler1

  • 1Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Translational Andrology and Urology
|January 13, 2017
PubMed
Summary

Testosterone replacement therapy (TRT) does not worsen benign prostatic hyperplasia (BPH) or lower urinary tract symptoms (LUTS). In fact, low testosterone (hypogonadism) is a significant risk factor for LUTS/BPH.

Keywords:
Benign prostatic hyperplasia (BPH)hypogonadismlower urinary tract symptoms (LUTS)testosterone replacement therapy (TRT)

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Area of Science:

  • Endocrinology
  • Urology
  • Men's Health

Background:

  • Testosterone replacement therapy (TRT) is increasingly used for late-onset hypogonadism (LOH).
  • The FDA warns TRT may worsen benign prostatic hyperplasia (BPH), despite unsubstantiated beliefs.
  • Understanding testosterone's role in prostate and urinary tract physiology is crucial.

Conclusions:

  • TRT is a safe and potentially beneficial treatment for men with LOH regarding prostate and urinary health.
  • Addressing hypogonadism may help manage or prevent LUTS/BPH.